Table 2.
Characteristics at inclusion of 129 PTB patients according to treatment outcome.
| Variables | Declared cured | p-values | |
|---|---|---|---|
| Yes (n = 98) | No (n = 31) | ||
| Age (years) | |||
| Median (IQR) | 40 (31–48) | 45 (34–50) | 0.22 |
| Sex | |||
| Female | 50 (51%) | 10 (32%) | 0.07 |
| Male | 48 (49%) | 21 (68%) | |
| BMI (kg/m2) | |||
| Median (IQR) | 16 (15–18) | 17 (15–17) | 0.37 |
| Work in mining | |||
| No | 33 (34%) | 11 (36%) | 0.85 |
| Yes | 65 (66%) | 20 (64%) | |
| Work in mining (years) | |||
| Median (IQR) | 10 (5–15) | 12 (9–15) | 0.26 |
| Tobacco smoking | |||
| No | 88 (8%) | 28 (90%) | 0.81 |
| Yes | 8 (8%) | 3 (10%) | |
| Xpert MTB/RIF (+) | |||
| No | 92 (94%) | 29 (94%) | 0.94 |
| Yes | 6 (6%) | 2 (6%) | |
| New case | |||
| No | 14 (14%) | 5 (17%) | 0.74 |
| Yes | 84 (86%) | 25 (83%) | |
| HIV-infection | |||
| No | 82 (84%) | 19 (61%) | 0.008 |
| Yes | 16 (16%) | 12 (39%) | |
| Telomere lengtha | |||
| Median (IQR) |
1.04 (0.90–1.19) (n = 92) |
0.92 (0.77–1.04) (n = 30) |
0.02 |
| mtDNAb | |||
| Median (IQR) |
1.08 (1.02–1.21) (n = 92) |
0.99 (0.81–1.20) (n = 29) |
0.18 |
Data are shown as n (%) otherwise as median and interquartile range (IQR).
BMI body mass index, Xpert MTB/RIF automated diagnostic test for rapid identification of Mycobacterium tuberculosis DNA and resistance to rifampicin (RIF).
aLeukocyte TL and mtDNA is expressed in relative units as the ratio of telomere copy number was proportional to single-copy gene number (T/S) relative to the average telomere length and mtDNA content respectively. T/S ratio of the entire sample set (n = 122).
bLeukocyte mtDNA is expressed in relative units as the ratio of ND1 copy number to single-copy gene number relative to the average ratio of the entire sample set (n = 121).
p-values refer to difference between declared cured vs not declared cured (without adjustments).