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. 2021 Feb 4;11:615618. doi: 10.3389/fmicb.2020.615618

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Copyright © 2021 Pietsch, Heidrich, Nordholt and Schreiber.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Synergy and antagonism between antibiotics and biocides based on Bliss interaction scores. Red colors depict antagonistic and blue colors depict synergistic interactions. Combinations displayed in colors were significant according to a one-sample t-test (p < 0.05). Combinations displayed in gray were not significant. Note that our assay cannot fully exclude synergy or antagonism for those combinations shown in gray. These interactions might be detectable if more combinations of different concentrations are tested.