Table 2.

Univariable and multivariable association of IS classifier, clinicopathological characteristics with DFS in the training cohort.

	Univariate analysis		Multivariate analysis
	HR(95% CI)	P value	HR(95% CI)	P value
Gender	0.962(0.637–1.453)	0.855
Age	1.005(0.987–1.023)	0.614
T stage(T2+T3 vs. T1+T2)	2.602(1.772–3.822)	<0.01
N stage(N1+N2+N3 vs. N0)	3.052(1.338–6.955)	0.008
TNM stage(III vs. I+II)	3.744(2.386–5.875)	<0.01	2.279(1.278–4.055)	0.005
Lauren type	1.394(1.018–1.908)	0.038
Status of microsatellite (MSI vs. MSS)	1.356(1.039–1.770)	0.025
IS	1.794(1.492–2.158)	<0.01	1.581(1.279–1.954)	<0.01

MSS, microsatellite stability; MSI, microsatellite instability; HR, hazard ratio; IS, immunoscore.