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. 2021 Feb 4;11:603683. doi: 10.3389/fgene.2020.603683

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Copyright © 2021 Wu, Wang, Ding, Sun, Liu, Wang, Sheng, Zhang, Yang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MHY1485 treatment can stimulate the phosphorylation of proteins in the mTOR pathway. (A) Treatment of 1 μM, 3 μM, and 10 μM MHY1485 led to a dose-dependent increase in the phosphorylation of mTOR as well as downstream RSP6 protein levels without affecting total mTOR rpS6 expression. Treatment of 20 μM did not increase those protein levels further in comparison to 10 μM MYH1485. (B) Experiments were repeated three times. All data were compared with that of the control group. Data was applied to non-parametric tests for statistical analysis and presented as the mean ± SEM *P < 0.05, **P < 0.01, and the differences are significant.