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. 2021 Feb 4;12:628863. doi: 10.3389/fphys.2021.628863

TABLE 2.

Incidence of gastrointestinal symptoms and severity of gut discomfort, total, upper-, and lower-gastrointestinal symptoms in response to 2 h HIIT exercise (between 60 and 80% O2max) in temperate ambient conditions and after consumption of dairy milk (CM) and the carbohydrate-electrolyte (CEB) recovery beverages.

CM
CEB
Exercise
Recovery
Exercise
Recovery
Incidence Severity Incidence Severity Incidence Severity Incidence Severity
% (severe) % (severe) Acute (1–2 h) Total (1–4 h) % (severe) % (severe) Acute (1–2 h) Total (1–4 h)
Gut discomfort NA 5 (0–13) NA 5 (0–24) 14 (0–51) NA 5 (0–18) NA 4 (0–22) 11 (1–50)
Total GIS1 59 (0) 6 (4–18) 76 (47) 6 (3–24) 15 (3–51) 71 (12) 7 (2–31) 64 (35) 4 (1–22) 12 (1–50)
Upper GIS2 47 (0) 3 (3–10) 41 (29) 4 (10–24) 11 (2–51) 35 (0) 2 (1–11) 52 (24) 3 (1–22) 8 (2–50)
Belching 35 (0) 3 (3–10) 18 (0) 0 (1–1) 0 (1–2) 29 (0) 2 (1–11) 18 (0) 0 – 1 (2–4)
Heartburn 6 (0) 0 (3–3) 6 (0) 0 – 0 (4–4) 0 (0) 0 – 0 (0) 0 – 0 –
Bloating 12 (0) 0 (2–4) 35 (29) 4 (10–24) 10 (2–51) 12 (0) 0 (1–3) 41 (24) 3 (1–22) 7 (3–50)
Stomach pain 0 (0) 0 – 0 (0) 0 – 0 – 0 (0) 0 – 0 (0) 0 – 0 –
Urge to regurgitate 6 (0) 0 (1–1) 0 (0) 0 – 0 – 0 (0) 0 – 0 (0) 0 – 0 –
Regurgitation 0 (0) 0 – 0 (0) 0 – 0 – 0 (0) 0 – 0 (0) 0 – 0 –
Lower GIS2 24 (0) 1 (1–6) 42 (18) 1 (3–8) 3 (3–20) 18 (0) 1 (7–13) 35 (12) 1 (5–10) 3 (1–25)
Flatulence 12 (0) 0 (1–3) 12 (0) 0 – 0 (3–5) 18 (0) 1 (7–13) 24 (0) 0 – 1 (1–7)
Lower bloating 6 (0) 0 (2–2) 18 (0) 0 – 1 (2–11) 6 (0) 0 – 6 (6) 0 – 0 (8–8)
Urge to defecate 12 (0) 0 (1–3) 24 (0) 0 – 2 (2–12) 0 (0) 0 – 12 (6) 1 (5–10) 1 (5–10)
Intestinal pain 0 (0) 0 – 0 (0) 0 – 0 – 0 (0) 0 – 0 (0) 0 – 0 –
Abnormal defecation3 0 (0) 0 – 6 (6) 0 (6–6) 0 – 0 (0) 0 – 6 (6) 0 – 0 (10–10)
Others
Nausea 12 (0) 1 (1–11) 6 (0) 0 (5–5) 0 (5–5) 24 (6) 1 (1–12) 12 (0) 1 (4–7) 1 (4–7)
Dizziness 29 (0) 2 (2–12) 24 (0) 1 (1–7) 1 (1–7) 29 (6) 1 (1–11) 18 (0) 0 (1–3) 0 (1–3)
Stitch4 6 (0) 0 (1–1) 0 (0) 0 – 0 – 6 (0) 0 (4–4) 0 (0) 0 – 0 –
Feeding tolerance
Appetite NA 13 (0–39) NA 21 (3–35) 26 (5–43) NA 14 (0–38) NA 25 (8–43) 32a (9–58)
Thirst NA 23 (0–44) NA 16 (4–26) 21 (6–37) NA 23 (0–41) NA 19 (8–37) 26 (14–51)

Values are presented as means and range of participant reporting GIS incidence (n = 17). GIS incidence during exercise and recovery are presented as percentage of total participants reporting GIS ≥ 1 on the mVAS. GIS severity during exercise and recovery are presented as mean summative accumulation of mVAS rating scale of measured time periods and individual range of participant reporting GIS incidence (Gaskell et al., 2019, 2020b). 1Summative accumulation of upper-, lower-, and other gastrointestinal symptoms, 2summative accumulation of upper- or lower- gastrointestinal symptoms, 3abnormal defecation including loose watery stools, diarrhea and blood in stools, and 4acute transient abdominal pain. NA, not applicable. Wilcoxon signed-rank tests showed no differences between CM and CEB for GIS; however a p < 0.05 vs. CM for appetite. Hedge’s g measurement of effect size for GIS and feeding tolerance severity between CM and CEB was determined as >0.50 and >0.80 for medium and large effects, respectively; however, no medium or large effects size value were detected between CM and CEB.