Table 1.
Baseline characteristics of patients with decompensated cirrhosis stratified for outcome at 90 days follow up.
| All patients (n = 292) | Transplant-free survivors at 90 days∗ (n = 199) | Non-survivors/transplanted at 90 days (n = 93) | p value | |
|---|---|---|---|---|
| Age (years) | 59 (52–67) | 58 (50–65) | 63 (56–71) | <0.001 |
| Male sex (%) | 216 (74) | 149 (75) | 67 (72) | 0.67 |
| HCC at baseline (%) | 42 (14) | 23 (12) | 19 (20) | 0.05 |
| Alcoholic liver disease (%) | 232 (79) | 165 (83) | 67 (72) | 0.04 |
| Child-Pugh class C (%) | 182 (62) | 115 (58) | 67 (72) | 0.02 |
| MELD score | 17 (12–22) | 15 (11–20) | 20 (16–28) | <0.001 |
| ACLF | 78 (27) | 36 (18) | 42 (45) | <0.001 |
| ACLF | ||||
| Grade 1 | 44 (15) | 25 (13) | 19 (20) | 0.004 |
| Grade 2 | 21 (7) | 10 (5) | 11 (12) | |
| Grade 3 | 13 (4) | 1 (1) | 12 (13) | |
| SBP at baseline (%) | 39 (13) | 16 (8) | 23 (25) | <0.001 |
| Bilirubin (μmol/L) | 40 (20–97) | 35 (19–75) | 65 (25–173) | <0.001 |
| ALT (μmol/L) | 0.57 (0.38–0.93) | 0.54 (0.37–0.76) | 0.65 (0.42–1.20) | 0.02 |
| AST (μmol/L) | 1.08 (0.70–1.89) | 1.03 (0.68–1.65) | 1.17 (0.76–2.66) | 0.09 |
| INR | 1.4 (1.2–1.7) | 1.4 (1.2–1.6) | 1.5 (1.3–1.9) | 0.001 |
| Creatinine (μmol/L) | 95 (64–147) | 81 (62–126) | 136 (81–185) | <0.001 |
| WBC (/nl) | 6.8 (5.0–10.1) | 6.3 (4.6–9,3) | 8.4 (5.6–11.9) | <0.001 |
| CRP (mg/L) | 31 (16–61) | 25 (13–49) | 53 (25–87) | <0.001 |
Baseline characteristics are depicted as frequencies or median (IQR). Values of p are based on Wilcoxon–Mann–Whitney test for continuous and Fisher’s exact test for categorial variables.
ACLF, acute-on-chronic liver failure; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRP, C-reactive protein; HCC, hepatocellular carcinoma; MELD, model for end-stage liver disease; SBP, spontaneous bacterial peritonitis; WBC, white blood cell count.
∗
Including 40 patients lost to follow-up after a median of 14 days.