Table 2.
MIF and sCD74 serum concentrations stratified for clinical parameters and the presence and severity of ACLF.
| Serum MIF (ng/ml) |
Serum sCD74 (ng/ml) |
|||
|---|---|---|---|---|
| Median (IQR) | p value | Median (IQR) | p value | |
| Sex | ||||
| Female | 2.7 (1.4–6.0) | 0.25 | 37.1 (7.2–85.0) | 0.20 |
| Male | 3.2 (1.7–7.6) | 49.3 (6.1–118.7) | ||
| Aetiology | ||||
| Alcoholic | 3.0 (1.5–7.3) | 0.61 | 39.2 (6.1–111.7) | 0.26 |
| Non-alcoholic | 3.2 (1.8–6.8) | 64.2 (10.2–128.4) | ||
| Child-Pugh class | ||||
| B | 3.0 (1.6–7.4) | 0.84 | 38.8 (14.7–84.8) | 0.94 |
| C | 3.1 (1.5–7.3) | 48.5 (2.6–115.0) | ||
| HCC | ||||
| No | 3.0 (1.5–7.2) | 0.32 | 42.3 (5.7–111.4) | 0.67 |
| Yes | 3.5 (1.9–7.9) | 50.5 (13.0–143.4) | ||
| ACLF | ||||
| No | 3.0 (1.5–7.2) | 0.63 | 46.5 (9.2–114.1) | 0.67 |
| Yes | 3.5 (1.9–7.9) | 43.4 (0.6–110.9) | ||
| ACLF grade | ||||
| Grade 1 | 3.1 (1.7–7.1) | 0.49 | 43.1 (1.6–147.1) | 0.90 |
| Grade 2 | 3.6 (1.4–8.0) | 48.9 (1.4–111.0) | ||
| Grade 3 | 3.4 (2.6–8.0) | 37.2 (0.4–74.3) | ||
Medians with IQRs are depicted and p values from the Mann-Whitney U test or Kruskal-Wallis test are shown. ACLF, acute-on-chronic liver failure; HCC, hepatocellular carcinoma; MIF, macrophage migration inhibitory factor; sCD74, soluble receptor CD74.