Table 3.

Dichotomised serum concentrations of MIF and sCD74 indicate an increased risk of death or transplant within 90 days.

	Serum MIF Dichotomised ≥2.3 ng/ml		Soluble CD74 Dichotomised ≥66.5 ng/ml
	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Unadjusted	2.01 (1.26–3.22)	0.004	0.59 (0.38–0.92)	0.02
Adjusted for MELD	1.70 (1.06–2.75)	0.03	0.62 (0.40–0.97)	0.03
Adjusted for ACLF	1.88 (1.17–3.02)	0.009	0.59 (0.38–0.92)	0.02
Adjusted for WBC∗	1.75 (1.09–2.80)	0.02	0.64 (0.41–1.00)	0.05
Adjusted for CRP∗	1.76 (1.10–2.84)	0.02	0.65 (0.42–1.02)	0.06
Adjusted for ACLF and WBC∗	1.57 (1.07–2.32)	0.02	0.63 (0.40–0.99)	0.04
Adjusted for ACLF and CRP∗	1.67 (1.04–2.70)	0.03	0.64 (0.41–1.01)	0.055

Univariate and multivariable Cox regression analysis of the risk for death or transplant within 90 days using dichotomised serum levels of MIF and sCD74. In multivariable analysis, hazard ratios were adjusted for the MELD, presence of ACLF, and the inflammatory parameters WBC and CRP as indicated. Serum MIF and sCD74 were dichotomised according to the maximum Youden index. ACLF, acute-on-chronic liver failure; CRP, C-reactive protein; HCC, hepatocellular carcinoma; MELD, model for end-stage liver disease; MIF, macrophage migration inhibitory factor; sCD74, soluble receptor CD74; WBC, white blood cell count.

^∗Parameter was log_e-normalised.