Fig. 2.

Growth curves, body composition, and organ weights in liver-specific knockout (LKO) mice and sex- and age-matched controls (CTL). The growth velocity of male (A) and female mice (B) was comparable between the liver-specific knockout mice (Dhcr7^flx/flx,Cre+) compared with control mice (Dhcr7^flx/flx,Cre−), and although no differences in body fat (C) were noted, male knockout mice showed a statistically significant lower lean body mass (D), though these differences are quite small (measured at 10–14 weeks of age). There were no differences in the liver (E) or spleen (F) weights at sacrifice at 13–14 weeks of age. Comparisons were made only within each sex. Males are represented by circles, and females by triangles. LKO mice are represented by open symbols and CTL mice by closed symbols. Bars denote the mean ± 1 SD. For body weight measurements in weeks 7–10, n = 27 male, 26 female Dhcr7^flx/flx,Cre+ mice and n = 9 males, 11 female Dhcr7^flx/flx,Cre− mice; in weeks 11–12, n = 18 male, 16–21 female Dhcr7^flx/flx,Cre+ mice and n = 6 males, 5–6 female Dhcr7^flx/flx,Cre− mice. For body composition measurements, n = 14 male LKO and CTL mice, 17 female LKO and 21 female CTL mice. For the liver and spleen weights, n = 15 mice per group.