Fig. 3.

Plasma sterol profiles in male liver-specific knockout (LKO) mice compared with controls (CTL). Weekly profiles of cholesterol (A), 7-dehydrocholesterol (B), desmosterol (C), 7-dehydrodesmosterol (D), lathosterol (E), and lanosterol (F) are shown. Liver knockout mice are represented by open circles and control mice by closed circles. As expected, 7-DHC (B) was characteristically elevated and desmosterol levels depressed (panel C) in liver-specific knockouts. In controls, 7-DHC levels were undetectable at all time points (B). Lathosterol levels were also statistically elevated at all time points in liver-specific male mice. Error bars denote ± 1 SD. (∗P < 0.05 vs. controls). N = 5–6 per group.