Fig. 7.

Biliary sterol profiles in liver-specific Dhcr7 knockout mice. Although biliary cholesterol was unaltered in liver-specific knockout mice compared with sex-matched controls (A), there was significant excretion of 7-DHC into bile of LKO mice and undetectable levels in CTL mice (B). Bile of LKO mice also demonstrated decreased desmosterol (C), increased 7-dehydrodesmosterol (D) and lathosterol (E), but no difference in lanosterol (F). Males are represented by circles, and females by triangles. LKO mice are represented by open symbols and CTL mice by closed symbols. Bars denote the mean ± 1 SD. (∗P < 0.05 vs. respective controls). N = 5–6 per group.