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. 2021 Feb 4;12:633467. doi: 10.3389/fmicb.2021.633467

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Copyright © 2021 Zhang, Xiong, Peng, Lu, Hao, Qin and Zeng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IBG inhibits S. aureus growth without detectable mutant development. (A) Structure of IBG. (B) Viability of S. aureus ATCC 29213 treated with IBG or VAN. (C) Viability of MRSA ATCC 43300 treated with IBG or VAN for 4 h. (D) IBG treatment could not result in S. aureus ATCC 29213 lysis; (E) Appearance of spontaneous IBG and CIP-resistant S. aureus mutants over 100 days of serial passages. IBG, isopropoxy benzene guanidine; VAN, vancomycin; CIP, ciprofloxacin; Individual data points (n = 3 biologically independent experiments) and mean ± SD. are shown.