Table 1.

Enzymes involved in the capture of leukocytes.

Enzyme type		Enzmye function	Effect on Leukocyte Capture	References
Polypeptide N-acetylgalactosmaine transferase	ppGalNT1	Connects glycan to peptide	Crucial in glycosylation of ligands for P-selectin Knock down impedes leukocyte rolling, adhesion and transmigration Drosophila analogue of mammalian ppGalNT, alternative splicing alters substrate and peptide preference	Tenno et al., 2007 Block et al., 2012 May et al., 2020
	PGANT
Fucosyltransferase	Fut IV Fut VII Fut IX	Addition of fucose to glycan	Necessary for fucosylation of PSGL-1 Knock downs decrease interaction with selectins in vitro and in vivo under flow Expression of Fut VII increased in activated T-cells so they can bind to selectins	Buffone et al., 2013 Chen et al., 2016 Hobbs and Nolz, 2017