Table 2.

Enzymes involved in Leukocyte Adhesion and Transmigration.

Enzyme type		Enzyme Function	Effect on Leukocyte adhesion and transmigration	References
N-acetylglucosaminyl-transferase	GNT-V	Addition of GlcNAc to OH-group of α-linked mannose	IFNγ-mediated decrease of GNT-V caused decrease of β-1,6-linked GalNAc on integrins, resulting in IFNγ-mediated adhesion of monocytes	Yang et al., 2012
Mannosidase		Remove mannose from glycan	TNFα treatment of EC downregulates mannosidase in turn resulting in high-mannose N-glycans on EC High-mannose ICAM-1 selectively recruits non-classical (CD16+) monocytes Oscillatory shear stress increases mannose on EC	Chacko et al., 2011 McDonald et al., 2020 Scott et al., 2012
Sialyltransferase	St6Gal1	Addition of α-2,6-linked sialic acid to terminal N-glycans	Needed for PECAM-1 presentation on EC surface	Kitazume et al., 2010