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. 2021 Feb 4;9:592946. doi: 10.3389/fcell.2021.592946

Figure 5.

Figure 5

Osteogenic differentiation in hBM-MSCs cells is regulated by exposure to TRPM8 channel modulators. (A) Percentage of differentiated area from hBM-MSCs, detected with Alizarin Red (n = 3). Negative control (Control -), ****P < 0.0001; 100 μM menthol, **P < 0.001; 20 μM BCTC, *P < 0.01; 10 μM Icilin, **P < 0.001; (n = 3). (B) Rate of change measured by qPCR of the ALPL gene after 14 days of osteogenic differentiation; Negative control (Control -), *P < 0.01; BCTC 20 μM, **P < 0.001; 100 μM Menthol, **P < 0.001.