Table 2.
Brain regions with high predictive accuracy identified by MVPA and the corresponding post-hoc (VBM) results, which was corrected for multiple comparisons using family wise error (FWE) at the cluster level (p < 0.05).
| Brain regions (AAL) | Cluster size (voxels) | Peak MNI coordinates | Peak t-value | ||
|---|---|---|---|---|---|
| X | Y | Z | |||
| Temporal_Pole_Mid_R | 78 | 42 | 7.5 | −37.5 | 3.69 |
| Occipital_Inf_L | 64 | −36 | −73.5 | −0.5 | −3.87 |
| Calcarine_L | 525 | 1.5 | −79.5 | −3 | −4.62 |
| Frontal_Med_Orb_L | 89 | −13.5 | 63 | −3 | 3.91 |
| Postcentral_R | 622 | 24 | −37.5 | 81 | 4.17 |
| Temporal_Inf_L | 143 | −54 | −39 | −19.5 | −4.12 |
| Lingual_L | 197 | 1.5 | −78 | −1.5 | −4.32 |
| Cuneus_L | 317 | −1.5 | −97.5 | 18 | 4.19 |
| Angular_R | 449 | 45 | −75 | 40.5 | 3.89 |
| Occipital_Sup_L | 294 | −13.5 | −99 | 31.5 | 4.30 |
| Frontal_Mid_R | 217 | 31.5 | 42 | 9 | 4.50 |
| Parietal_Sup_R | 98 | 15 | −72 | 70.5 | 3.95 |
AAL, anatomical automatic labeling; MNI, Montreal Neurological Institute; L, left hemisphere; R, right hemisphere; acc, accuracy; HS, heavy smokers; HC, healthy controls. Peak t-value, post-hoc (VBM) results, conducted on brain regions detected by MVPA and corrected for multiple comparisons using family wise error (FWE) at the cluster level (p < 0.05). Positive t-value indicates GM volume in HS is significantly smaller than HC while negative value indicates the opposite.