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. 2020 Nov 26;12(1):144–158. doi: 10.1002/jcsm.12646

FIGURE 4.

FIGURE 4

Myosteatosis is the earliest muscle alteration in mice with non‐alcoholic steatohepatitis. (A) Non‐alcoholic fatty liver disease activity score (NAS) of wild‐type normal diet (WT ND), WT high‐fat‐(HF) fed (WT HF), and HF diet‐fed fat aussie (FOZ HF) mice according to time point studied (n = 5–9 per group per time point). (B) Body weight, (C) homeostatic model assessment of insulin resistance (HOMA‐IR), (D) visceral fat area (L4), (E) dorsal muscle area (L4 and L5 averaged), (F) grip strength, and (G) dorsal muscle density (L4 and L5 averaged) measured in vivo by micro‐CT in WT ND, WT HF, and FOZ HF during feeding experiment (n = 5–19 per group per time point, two‐way ANOVA: $ = FOZ HF significantly different from WT ND; # = WT HF significantly different from WT ND; 38; = FOZ HF significantly different from WT HF). W, weeks.