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. 2020 Nov 24;12(1):130–143. doi: 10.1002/jcsm.12636

FIGURE 6.

FIGURE 6

Effect of hindlimb suspension and reloading on mTORC1 signalling pathway. Phosphorylation of p70S6K at Thr389, a direct target of mTORC1 in plantaris (A) and soleus (B). Measurement of the γ isoform (hyperphosphorylated state) of 4E‐BP1 in plantaris (C) and soleus (D). Values are mean ± SEM (n = 4–5 per time point). Data in B failed normality test and were log‐transformed prior to statistical analysis. * indicates significantly different than weight bearing; %, significantly different than HS 24 h; #, significantly different than HS 7d (all P ≤ 0.05). Representative blots and theoretical representation of the effect of loading and reloading on translational efficiency markers (J). HS, hindlimb suspension; WB, weight bearing.