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. 2021 Feb 14;12(1):209–232. doi: 10.1002/jcsm.12665

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© 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Differentiation dynamics of hiPSCs (D0) into MyoT (D25) in Duchenne muscular dystrophy (DMD) cells. (A) Dotplot of DMD/healthy expression ratios of selected differentiation markers. Statistical differences are indicated in brackets after gene names and grey circles around the corresponding dots. (B) Proportions of significantly dysregulated mRNAs (adjusted P value ≤ 0.05) in DMD cells at each time point. Expression of (C) MIR1–1 and (D) ATP2A2 mRNA during differentiation. (E) ATP2A2 protein level at D17 (*adjusted P value ≤ 0.05, **adjusted P value ≤ 0.01, ***adjusted P value ≤ 0.001, ****adjusted P value ≤ 0.0001; D: day; hiPSC: human induced pluripotent stem cell; MyoT: myotube).