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. 2021 Feb 14;12(1):209–232. doi: 10.1002/jcsm.12665

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© 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Illustration of the fibrosis phenotypes in Duchenne muscular dystrophy (DMD) cells. Volcano plots of dysregulated mRNAs/miRNAs related to (A) the SHH pathway and collagen metabolism at D10/17/25 and (B) fibrosis at D25—vertical grey dashed lines represent DMD/healthy ratio thresholds at 0.76 or 1.32, and the horizontal grey dashed line represents the adjusted P value threshold at 0.05 (D: day; MMP: matrix metallopeptidase; SHH: sonic hedgehog pathway; TIMP: tissue inhibitor of metallopeptidase; TGF: transforming growth factor).