$e{m}_{wl}$	The released ${\mathrm{CO}}_2$ cost through established DC $w$ with the capacity level $l$
$c{r}_m$	The released ${\mathrm{CO}}_2$ cost through a unit medicine shipping $m$ in the one KM
$m{a}_{ml}^{\prime }$	The mass of one unit of type $m$ medicine stored in DC with capacity level $l$
$m{a}_{mw}$	The mass capacity of DC $w$ to store type $m$ medicine
$vo{l}_{mw}$	The volumetric capacity of DC $w$ for medicine $m$
$vo{l}_{ml}^{\prime }$	The volume of one unit of medicine $m$ in DC with capacity level $l$
$n{f}_w^l$	The number of created fixed jobs in the establishment DC $w$ with capacity level $l$
$n{v}_w^l$	The number of created variable jobs in the establishment DC $w$ with capacity level $l$
$we$	Importance of job opportunity criteria
$w{e}^{\prime }$	Importance of economic development criteria
$r{w}_w$	Unemployment rate of established DC $w$
$B{d}_g$	Available budget to permanent centers $g$
$e{w}_w^l$	The economic value of the location of the establishment DC $w$ with capacity level $l$
$r{d}_w$	The level of regional development in an established DC $w$
$ps{h}_{mh}$	Penalty of medicine $m$ shortage in hospital $h$
$ps{u}_{mh}$	Penalty of medicine $m$ surplus in hospital $h$
$s_{mh}$	Upper bound of the penalty of medicine $m$ shortage in hospital $h$
$c{p}_{gm}$	The storage capacity of medicine $m$ in permanent center $g$
$c{w}_{w{w}^{\prime }m}^{\prime }$	Transportation cost of medicine $m$ between DCs $w$ and $w^{\prime }$
$c{w}_{whm}$	Transportation cost of medicine $m$ between DC $w$ hospital $h$
$c{t}_{gwm}$	Transportation cost of medicine $m$ between permanent center $g$ and DC $w$
$cs{w}_{wl}$	The establishing cost of DC $w$ with capacity level $l$
$co{w}_{wl}$	The operating cost of DC $w$ with capacity level $l$
$f_{gm}$	Inventory cost of medicine $m$ in permanent center $g$
$p{c}_{mit}$	Production cost of medicine $m$ in the medicine production laboratory $i$ at the period $t$
$p{r}_{mh}$	The importance medicine $m$ in hospital $h$
$d_{hmt}$	The demand of medicine $m$ in hospital $h$ at the period $t$
$j_m$	The holding time of medicine $m$
$s{m}_{m{m}^{\prime }}$	Medicine substitution matrix $m$ instead of $m^{\prime }$. 1 if it can be replaced, otherwise 0