$I_{wmtre}^{\prime }$	The amount of inventory medicine $m$ in DC $w$ at the period $t$ which are produced at the period $r$ and are shipped at the period $e$.
$I_{gmtr}$	The amount of inventory medicine $m$ in permanent center $g$ at the period $t$ which are produced at the period $r$
$A_{mit}$	The amount of medicine $m$ produced in the medicine production laboratory $i$ at the period $t$
$H_{w{w}^{\prime }mt}$	Medicine flow m between the DCs $w$ and $w^{\prime }$ at the period $t$
$y_{mht}^{\prime }$	Surplus of type $m$ medicine in hospital $h$ at the period $t$
$y_{mht}^{\prime \prime }$	The amount of medicine shortage $m$ in hospital $h$ at the period $t$
$l{i}_{gt}^m$	The amount of medicine inventory $m$ in permanent center $g$ at the period $t$
$x_{igmt}$	Medicine flow m between laboratory $i$ and permanent center $g$ at the period $t$
$x_{mhwt}^1$	Medicine flow m between DC $w$ and hospital $h$ at the period $t$
$x_{mgwt}^2$	Medicine flow m between permanent center $g$ and DC $w$ at the period $t$
$f_{whmret}$	Medicine flow m between DC $w$ and hospital $h$ at the period $t$, which are produced at the period $r$ and are shipped at the period $e$
$Q_{gwmrt}$	Medicine flow m between permanent center $g$ and DC $w$ at the period $t$, which are produced at the period $r$
$O_{w{w}^{\prime }mret}$	Medicine flow m between DCs $w$ and $w^{\prime }$ at the period $t$, which are produced at the period $r$ and are shipped at the period $e$
$y_{wl}$	1 if the DC $w$ is established with capacity level $l$, otherwise 0.
$Z_{git}$	1 if permanent center $g$ is allocated to laboratory $i$ at the period $t$, 0 otherwise
$Z_{wgt}$	1 if DC $w$ is allocated to permanent center $g$ at the period $t$, 0 otherwise
$Z_{hwt}$	1 if hospital $h$ is allocated to DC $w$ at the period $t$, 0 otherwise