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. 2021 Jan 16;12(6):1678–1686. doi: 10.7150/jca.50888

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circ_SMAD2/miR-1258/RPN2 axis in CRC. (A, B) miR-1258 suppression (or RPN2 upregulation) abolished the effects of circ_SMAD2 suppression on RPN2 in CRC cells. (C-E) miR-1258 suppression (or RPN2 upregulation) abolished the effects of circ_SMAD2 suppression on the proliferation and invasion of CRC cells. (F, G) After 35 days, the mice were sacrificed, and the tumors were weighed. (H) The levels of circ_SMAD2, miR-1258 and RPN2 were detected by qRT-PCR. (I) The circ_SMAD2/miR-1258/RPN2 axis in CRC. *p<0.05.