Table 1.
Characteristics of the included studies
| Author | Year | Country | No.of patients | Age(years) | Data collection | Specimens | Test methods |
Cut-off value | Stage | Analysis index | Follow-up months | Analysis methods | NOS score | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (mean or median) | |||||||||||||||
| Fn-high | Fn-low | Fn-high | Fn-low | ||||||||||||
| Yanglong Chen | 2019 | China | 35 | 66 | 58.72±12.638 | 58.52±10.421 | Retro | tissues | qPCR | 2-ΔCt | II~III | OS | 120 | MA | 5 |
| Kosuke Mima | 2016 | America | 67 | 917 | 68.8 ± 8.3 | 69.2 ± 8.9 | Pro | tissues | qPCR | 2-ΔCt | I~IV | OS, CSS | 120 | MA, UA | 7 |
| Andrew T. Kunzmann | 2019 | CzechRepublic | 61 | 129 | NR | NR | Retro | tissues | qPCR | 2-ΔCt | I~IV | OS | 72 | UA | 5 |
| Katsuhiko Nosho | 2016 | Japan | 44 | 463 | 65.0 ± 12.1 | 67.3 ± 11.7 | Retro | tissues | qPCR | NR | I~IV | NR | NR | NR | 4 |
| Hyeon Jeong Oh | 2019 | South Korea | 204 | 389 | >18 | >18 | Retro | tissues | qPCR | 2-ΔCt | II~III | DFS | 120 | MA | 6 |
| Yuan Sun | 2016 | China | 118 | 34 | 28-84 | 28-84 | Retro | tissues | qPCR | 2-ΔCt | I~IV | OS | 60 | UA | 5 |
| Zhiliang Wei | 2016 | China | 90 | 90 | NR | NR | Retro | tissues | 16sRNA | 0.52% | I~IV | OS, DFS | 36 | MA | 5 |
| Yuko Yamaoka | 2017 | Japan | 50 | 50 | 62.5 ± 9.8 | 63.9 ± 14.5 | Retro | tissues | droplet digital PCR | NR | I~IV | OS | 120 | UA | 6 |
| Xuebing Yan | 2017 | China | 187 | 93 | NR | NR | Retro | tissues | qPCR | 2-ΔCt | I~IV | CSS, DFS | 60 | MA, UA | 6 |
| Yongyu Chen | 2017 | China | 61 | 27 | 58 | 59.4 | Retro | tissues | 16sRNA, FISH | NR | I~IV | NR | NR | NR | 4 |
| Bundgaard-Nielsen | 2019 | Denmark | 29 | 60 | 71 ±10.1 | 71 ±10.1 | Retro | tissues | 16sRNA | NR | I~IV | OS, DFS | 96 | UA | 5 |
| Dae-Won Lee | 2018 | Korea | 64 | 64 | NR | NR | Retro | tissues | qPCR | 2-ΔCt | II~III | OS, DFS | 96 | MA | 6 |
| Ana Carolina de Carvalho | 2019 | Brasil | 18 | 134 | 60.63 ± 13.7 | 60.63 ± 13.7 | Retro | tissues | qPCR | 2-ΔCt | I~IV | OS, CSS | 96 | UA | 5 |
Pro prospective, Retro retrospective. CRC colorectal cancer. qPCR quantitative polymerase chain reaction, 16sRNA 16S ribosomal RNA sequencing, droplet digital PCR polymerase chain reaction polymerase chain reaction, qrT-PCR quantitative reverse transcription polymerase chain reaction, FISH fluorescence in situ hybridization. NR not report. OS overall survival, DFS disease-free survival, MA multivariate analysis, UA univariate analysis.