Table 3.
Association between high F.nuleatum abundance and molecular characteristic of patients with CRC
| Factors | No. of studies | No. of patients | Pooled OR (95%CI) | P-value | Heterogenelty | Statistical method | |
|---|---|---|---|---|---|---|---|
| I2 (%) | P-value | ||||||
| MSI | 6 | 2520 | 2.53 (1.53, 4.20) | 0.0003 | 83% | <0.0001 | Random |
| KRAS | 6 | 2404 | 1.27 (1.00, 1.61) | 0.05 | 28% | 0.23 | Fixed |
| BRAF | 6 | 2499 | 1.93 (0.91, 4.11) | 0.09 | 65% | 0.01 | Random |
| MLH1 | 3 | 1211 | 0.78 (0.06, 9.39) | 0.84 | 94% | <0.0001 | Random |
| PIK2CA | 3 | 1603 | 1.21 (0.74, 1.97) | 0.45 | 0% | 0.86 | Fixed |
MSI microsatellite instability, KRAS k-ras gene mutation, BRAF b-raf gene mutation, MLH1 MLH1 hypermethylation, PIK2CA PIK3CA gene mutation.