TABLE 2.
Myocardial ischemia (MI) related genes targeted by active compounds of HLJDT.
| No. | GC id | Gene symbol | Description | Gifts | Relevance score |
|---|---|---|---|---|---|
| 1 | GC06P043770 | VEGFA | Vascular endothelial growth factor A | 56 | 42.46 |
| 2 | GC07M095297 | PON1 | Paraoxonase 1 | 53 | 34.38 |
| 3 | GC01M159682 | CRP | C-reactive protein | 53 | 30.85 |
| 4 | GC07P022765 | IL6 | Interleukin 6 | 55 | 29.21 |
| 5 | GC07P150990 | NOS3 | Nitric oxide synthase 3 | 57 | 28.06 |
| 6 | GC13P113105 | F7 | Coagulation factor VII | 53 | 25.95 |
| 7 | GC06P151656 | ESR1 | Estrogen receptor 1 | 60 | 22.36 |
| 8 | GC04M184627 | CASP3 | Caspase 3 | 57 | 21.69 |
| 9 | GC19P010270 | ICAM1 | Intercellular adhesion molecule 1 | 57 | 21.05 |
| 10 | GC14P061695 | HIF1A | Hypoxia inducible factor 1 subunit alpha | 54 | 20.97 |
| 11 | GC01M169722 | SELE | Selectin E | 50 | 18.15 |
| 12 | GC03P012328 | PPARG | Peroxisome proliferator activated receptor γ | 59 | 15 |
| 13 | GC01P100719 | VCAM1 | Vascular cell adhesion molecule 1 | 52 | 14.66 |
| 14 | GC01M226360 | PARP1 | Poly (ADP-ribose) polymerase 1 | 56 | 13.37 |
| 15 | GC18M063123 | BCL2 | BCL2 apoptosis regulator | 59 | 13.22 |
| 16 | GC09P122370 | PTGS1 | Prostaglandin-endoperoxide synthase 1 | 53 | 12.81 |
| 17 | GC04M148078 | NR3C2 | Nuclear receptor subfamily 3 group C2 | 54 | 11.91 |
| 18 | GC10P094938 | CYP2C9 | Cytochrome P450 family 2 subfamily C9 | 56 | 11.21 |
| 19 | GC01M015565 | CASP9 | Caspase 9 | 54 | 8.69 |
| 20 | GC07P116524 | CAV1 | Caveolin 1 | 54 | 8.02 |
| 21 | GC07M134442 | AKR1B1 | Aldo-keto reductase family 1 member B | 54 | 6.9 |
| 22 | GC10P045338 | ALOX5 | Arachidonate 5-lipoxygenase | 54 | 6.8 |
| 23 | GC14P075278 | FOS | Fos proto-oncogene | 57 | 6.58 |
| 24 | GC10P048306 | MAPK8 | Mitogen-activated protein kinase 8 | 56 | 6.33 |
| 25 | GC07M045912 | IGFBP3 | Insulin like growth factor binding protein 3 | 51 | 6.13 |
| 26 | GC02M177227 | NFE2L2 | Nuclear factor, erythroid 2 like 2 | 54 | 5.98 |
| 27 | GC07P076302 | HSPB1 | Heat shock protein family B (small) member 1 | 57 | 5.76 |
| 28 | GC07P144396 | MGAM | Maltase-glucoamylase | 48 | 5.03 |
| 29 | GC11M100943 | PGR | Progesterone receptor | 57 | 5.02 |
| 30 | GC02P188974 | COL3A1 | Collagen type III alpha 1 chain | 53 | 4.9 |
| 31 | GC03M012583 | RAF1 | Raf-1 proto-oncogene | 62 | 4.42 |
| 32 | GC17P066302 | PRKCA | Protein kinase C alpha | 57 | 4.28 |
| 33 | GC10P073909 | PLAU | Plasminogen activator, urokinase | 58 | 3.96 |
| 34 | GC05M132481 | IRF1 | Interferon regulatory factor 1 | 54 | 3.8 |
| 35 | GC03M119821 | GSK3B | Glycogen synthase kinase 3 beta | 57 | 3.78 |
| 36 | GC11M002130 | IGF2 | Insulin like growth factor 2 | 54 | 3.72 |
| 37 | GC11M063003 | CHRM1 | Cholinergic receptor muscarinic 1 | 52 | 3.64 |
| 38 | GC02P201233 | CASP8 | Caspase 8 | 59 | 3.57 |
| 39 | GC04M085990 | MAPK10 | Mitogen-activated protein kinase 10 | 57 | 3.56 |
| 40 | GC11M001752 | CTSD | Cathepsin D | 59 | 3.2 |
| 41 | GC07P136868 | CHRM2 | Cholinergic receptor muscarinic 2 | 54 | 3.14 |
| 42 | GC11P067583 | GSTP1 | Glutathione S-Transferase pi 1 | 57 | 3.13 |
| 43 | GC11M065671 | RELA | RELA proto-oncogene, NF-KB subunit | 56 | 3.07 |
| 44 | GC05M143241 | NR3C1 | Nuclear receptor subfamily 3 group C1 | 57 | 2.76 |
| 45 | GC11P113974 | HTR3A | 5-Hydroxytryptamine receptor 3A | 53 | 2.65 |
| 46 | GC07M099759 | CYP3A4 | Cytochrome P450 family 3 subfamily A4 | 56 | 2.6 |
| 47 | GC17M037084 | ACACA | Acetyl-CoA carboxylase alpha | 55 | 2.53 |
| 48 | GC17P007282 | SLC2A4 | Solute carrier family 2 member 4 | 53 | 2.51 |
| 49 | GC01P109687 | GSTM1 | Glutathione S-Transferase mu 1 | 48 | 2.42 |
| 50 | GC07M100889 | ACHE | Acetylcholinesterase (cartwright blood group) | 52 | 2.34 |
| 51 | GC08M026747 | ADRA1A | Adrenoceptor alpha 1A | 53 | 2.31 |
| 52 | GC08P127735 | MYC | MYC proto-oncogene | 59 | 2.23 |
| 53 | GC04P003804 | ADRA2C | Adrenoceptor alpha 2C | 51 | 2.17 |
| 54 | GC17P078214 | BIRC5 | Baculoviral IAP repeat containing 5 | 53 | 2.16 |
| 55 | GC0XP067544 | AR | Androgen receptor | 59 | 2.11 |
| 56 | GC11P069641 | CCND1 | Cyclin D1 | 59 | 2.01 |
| 57 | GC14M035401 | NFKBIA | NFKB inhibitor alpha | 57 | 1.98 |
| 58 | GC14M064084 | ESR2 | Estrogen receptor 2 | 56 | 1.9 |
| 59 | GC07P055019 | EGFR | Epidermal growth factor receptor | 62 | 1.82 |
| 60 | GC05P087267 | RASA1 | RAS P21 protein activator 1 | 53 | 1.66 |
| 61 | GC17P039687 | ERBB2 | Erb-B2 receptor tyrosine kinase 2 | 62 | 1.64 |
| 62 | GC02M038034 | CYP1B1 | Cytochrome P450 family 1 subfamily B1 | 56 | 1.63 |
| 63 | GC16M069706 | NQO1 | NAD(P)H quinone dehydrogenase 1 | 56 | 1.5 |
| 64 | GC08P042247 | IKBKB | Inhibitor of nuclear factor kappa B kinaseβ | 59 | 1.42 |
| 65 | GC01M070852 | PTGER3 | Prostaglandin E receptor 3 | 53 | 1.42 |
| 66 | GC01P239386 | CHRM3 | Cholinergic receptor muscarinic 3 | 55 | 1.32 |
| 67 | GC02P074796 | HK2 | Hexokinase 2 | 53 | 1.25 |
| 68 | GC08P144291 | HSF1 | Heat shock transcription factor 1 | 51 | 1.25 |
| 69 | GC11M065909 | FOSL1 | FOS like 1, AP-1 transcription factor subunit | 50 | 1.2 |
| 70 | GC15M074719 | CYP1A1 | Cytochrome P450 family 1 subfamily A1 | 53 | 0.78 |
| 71 | GC17M082078 | FASN | Fatty acid synthase | 56 | 0.73 |
| 72 | GC07P016916 | AHR | Aryl hydrocarbon receptor | 56 | 0.64 |
| 73 | GC19P040991 | CYP2B6 | Cytochrome P450 family 2 subfamily B6 | 55 | 0.6 |
| 74 | GC07M081946 | CACNA2D1 | Calcium voltage-gated channel auxiliary subunit α21δ | 53 | 0.3 |
| 75 | GC0XM047635 | ELK1 | ETS transcription factor ELK1 | 50 | 0.26 |