Table 2.
Characteristics on admission of CORONADO participants, according to discharge within 28 days
| Discharge within 28 days | |||||||
|---|---|---|---|---|---|---|---|
| Variable | Available data | All (N = 2796) | No (n = 1392) | Yes (n = 1404) | Unadjusted OR (95% CI) | Age-adjusted OR (95% CI) | Age-adjusted p value |
| Time from symptom onset to hospital admission (days) | 2743 | 5 (2–9) | 4 (2–7) | 6 (3–9) | 1.05 (1.04, 1.07) | 1.04 (1.02, 1.05) | <0.001 |
| Clinical presentation | |||||||
| Fever | 2755 | 2077/2755 (75.4) | 1031/1364 (75.6) | 1046/1391 (75.2) | 0.98 (0.82, 1.16) | 0.85 (0.71, 1.01) | 0.068 |
| Dyspnoea | 2754 | 1771/2754 (64.3) | 942/1364 (69.1) | 829/1390 (59.6) | 0.66 (0.57, 0.77) | 0.62 (0.52, 0.73) | <0.001 |
| Abnormal chest CT scan | 1982 | 1919/1982 (96.8) | 898/927 (96.9) | 1021/1055 (96.8) | 0.97 (0.59, 1.60) | 0.83 (0.49, 1.39) | 0.48 |
| Biological findings | |||||||
| Positive SARS-CoV-2 PCR | 2705 | 2547/2705 (94.2) | 1286/1340 (96.0) | 1261/1365 (92.4) | 0.51 (0.36, 0.71) | 0.46 (0.33, 0.66) | <0.001 |
| Admission plasma glucose (mmol/l) | 1551 | 9.5 (7.0–13.5) | 10.0 (7.1–14.0) | 9.1 (6.9–12.8) | 0.89 (0.80, 0.98) | 0.82 (0.73, 0.91) | <0.001 |
| Plasma creatinine (μmol/l) | 2602 | 91 (69–133) | 103 (75–153) | 84 (65–115) | 0.69 (0.63, 0.75) | 0.73 (0.67, 0.80) | <0.001 |
| eGFR (ml min−1 [1.73 m]−2)a | 2602 | 68.5 (41.8–89.7) | 57.1 (34.5–82.7) | 78.5 (52.0–95.6) | 1.57 (1.44, 1.71) | 1.36 (1.25, 1.49) | <0.001 |
| ALT (%ULN) | 2478 | 0.62 (0.42–1.00) | 0.62 (0.40–0.99) | 0.62 (0.43–1.00) | 0.96 (0.89, 1.04) | 0.87 (0.80, 0.95) | 0.002 |
| AST (%ULN) | 2444 | 1.06 (0.75–1.60) | 1.17 (0.80–1.85) | 0.98 (0.70–1.38) | 0.68 (0.62, 0.74) | 0.64 (0.58, 0.71) | <0.001 |
| GGT (%ULN) | 2317 | 0.95 (0.55–1.77) | 0.99 (0.56–1.88) | 0.92 (0.55–1.63) | 0.89 (0.82, 0.96) | 0.85 (0.78, 0.92) | <0.001 |
| Haemoglobin (g/l) | 2728 | 127 (114–142) | 125 (110–141) | 129 (118–143) | 1.28 (1.18, 1.38) | 1.21 (1.12, 1.31) | <0.001 |
| White cell count (103/mm3) | 2726 | 6580 (5000–8818) | 6800 (5150–9370) | 6310 (4900–8400) | 0.82 (0.76, 0.88) | 0.82 (0.76, 0.89) | <0.001 |
| Lymphocyte count (103/mm3) | 2646 | 990 (690–1400) | 900 (600–1300) | 1100 (780–1470) | 1.29 (1.19, 1.40) | 1.23 (1.13, 1.33) | <0.001 |
| Platelet count (103/mm3) | 2725 | 201 (156–260) | 196 (150–254) | 205 (164–264) | 1.17 (1.08, 1.26) | 1.13 (1.04, 1.22) | 0.003 |
| CRP (mg/l) | 2612 | 86.0 (40.3–148.0) | 98.6 (49.2–166.5) | 73.0 (33.4–128.0) | 0.74 (0.68, 0.80) | 0.70 (0.65, 0.76) | <0.001 |
| LDH (U/l) | 1427 | 351 (266–498) | 402 (290–567) | 319 (250–419) | 0.60 (0.52, 0.70) | 0.56 (0.48, 0.66) | <0.001 |
| CPK (U/l) | 1385 | 132 (67–305) | 164 (72–416) | 108 (61–222) | 0.70 (0.62, 0.78) | 0.67 (0.60, 0.75) | <0.001 |
| Fibrinogen (g/l) | 1424 | 6.3 (5.0–7.4) | 6.3 (5.0–7.6) | 6.2 (5.0–7.3) | 0.99 (0.89, 1.10) | 0.96 (0.87, 1.07) | 0.51 |
Population size was N = 2796. Data shown are n (%) and or median (25th–75th percentile)
p values are calculated using Wald test (unadjusted and age-adjusted logistic regression). Quantitative variables were natural-log transformed and associated ORs correspond to an increase of 1 SD after standardisation, except for time from symptoms onset to hospital admission (1 day increase)
aeGFR determined by the CKD-EPI formula
Abbreviations: ALT, alanine aminotransferase; ULN, upper limit of normal; GGT, γ-glutamyl transferase; LDH, lactate dehydrogenase; CPK, creatine phosphokinase