Table 4.
Characteristics on admission in CORONADO participants, according to death within 28 days
| Death within 28 days | ||||||
|---|---|---|---|---|---|---|
| Variable | Available data | No (n = 2219) | Yes (n = 577) | Unadjusted OR (95% CI)a | Age-adjusted OR (95% CI)a | Age-adjusted p value |
| Time from symptom onset to hospital admission (days) | 2743 | 6 (3–9) | 4 (1–7) | 0.94 (0.92, 0.96) | 0.97 (0.95, 0.98) | <0.001 |
| Clinical presentation | ||||||
| Fever | 2755 | 1647/2190 (75.2) | 430/565 (76.1) | 1.05 (0.85, 1.30) | 1.28 (1.02, 1.60) | 0.034 |
| Dyspnoea | 2754 | 1338/2188 (61.2) | 433/566 (76.5) | 2.07 (1.67, 2.56) | 2.34 (1.87, 2.92) | <0.001 |
| Abnormal chest CT scan | 1982 | 1560/1615 (96.6) | 359/367 (97.8) | 1.58 (0.75, 3.35) | 2.05 (0.95, 4.46) | 0.069 |
| Biological findings | ||||||
| Positive SARS-CoV-2 PCR | 2705 | 2018/2155 (93.6) | 529/550 (96.2) | 1.71 (1.07, 2.73) | 1.92 (1.18, 3.12) | 0.008 |
| Admission plasma glucose (mmol/l) | 1551 | 9.2 (7.0–13.2) | 10.2 (7.1–14.5) | 1.07 (0.94, 1.21) | 1.21 (1.06, 1.38) | 0.005 |
| Plasma creatinine (μmol/l) | 2602 | 87 (66–121) | 121 (85–185) | 1.69 (1.54, 1.85) | 1.65 (1.49, 1.81) | <0.001 |
| eGFR (ml min−1 [1.73 m]−2)a | 2602 | 74.8 (47.6–93.1) | 45.7 (27.2–70.1) | 0.56 (0.51, 0.61) | 0.62 (0.56, 0.68) | <0.001 |
| ALT (%ULN) | 2478 | 0.63 (0.43–1.00) | 0.59 (0.39–0.98) | 1.01 (0.92, 1.12) | 1.15 (1.05, 1.27) | 0.004 |
| AST (%ULN) | 2444 | 1.03 (0.72–1.50) | 1.33 (0.87–2.03) | 1.46 (1.33, 1.60) | 1.58 (1.43, 1.75) | <0.001 |
| GGT (%ULN) | 2317 | 0.95 (0.56–1.75) | 0.95 (0.54–1.83) | 1.04 (0.94, 1.16) | 1.10 (0.99, 1.22) | 0.067 |
| Haemoglobin (g/l) | 2728 | 128 (115–142) | 124 (109–139) | 0.81 (0.74, 0.89) | 0.86 (0.78, 0.95) | 0.003 |
| White cell count (103/mm3) | 2726 | 6450 (4900–8510) | 7260 (5420–10,100) | 1.35 (1.23, 1.48) | 1.34 (1.22, 1.48) | <0.001 |
| Lymphocyte count (103/mm3) | 2646 | 1015 (710–1430) | 845 (550–1200) | 0.74 (0.66, 0.82) | 0.80 (0.72, 0.89) | <0.001 |
| Platelet count (103/mm3) | 2725 | 205 (159–263) | 186 (142–241) | 0.77 (0.70, 0.84) | 0.79 (0.72, 0.87) | <0.001 |
| CRP (mg/l) | 2612 | 80 (36–140) | 111 (59–181) | 1.49 (1.33, 1.66) | 1.62 (1.44, 1.82) | <0.001 |
| LDH (U/l) | 1427 | 338 (257–464) | 436 (311–620) | 1.97 (1.61, 2.42) | 2.20 (1.78, 2.72) | <0.001 |
| CPK (U/l) | 1385 | 120 (63–265) | 202 (82–485) | 1.45 (1.28, 1.65) | 1.52 (1.33, 1.74) | <0.001 |
| Fibrinogen (g/l) | 1424 | 6.3 (5.0–7.4) | 6.3 (4.9–7.5) | 1.04 (0.92, 1.18) | 1.10 (0.97, 1.24) | 0.13 |
Population size was N = 2796. Data shown are n (%) and or median (25th–75th percentile)
p values are calculated using Wald test (unadjusted and age-adjusted logistic regression). Quantitative variables were natural-log transformed and associated ORs correspond to an increase of 1 SD after standardisation, except for time from symptoms onset to hospital admission (1 day increase)
aeGFR determined by the CKD-EPI formula
Abbreviations: ALT, alanine aminotransferase; ULN, upper limit of normal; GGT, γ-glutamyl transferase; LDH, lactate dehydrogenase; CPK, creatine phosphokinase