TABLE 1.

Nesfatin-1 concentrations in the CSF with or without direct injection of antibody or inhibitor into the lateral ventricle.

Group	Drug	Nesfatin-1 concentration (ng/ml)
Control	Saline	0.29 ± 0.083
Anti-nesfatin-1 antibody	2 μl nesfatin-1 (0.12 mg/ml)	0.02 ± 0.010*
Non-immune anti-mouse IgG antibody	2 μl IgG1κ antibody (1.3 mg/ml)	0.33 ± 0.019
MC4R receptor inhibitor	0.5 μl SHU 9119 (0.5 nmol)	0.31 ± 0.065

The drugs were administered to mice by ICV injection once daily for 14 days. The data represent the mean ± SD. n = 6 per group. *p < 0.05, compared to the controls. MC4R, Melanocortin 4 receptor.