Figure 1. Landscape of sequence annotation information updates.

1. Schematic representation of mapping chemoproteomic‐detected amino acids (CpDAAs) to pathogenicity scores.
2. Timeline of gene annotation database release dates and project‐specific datasets, including Ensembl releases tested for compatibility (Fig 2) to CpDAA coordinates based on canonical UniProtKB protein sequences and the database reference corresponding to the genomic pathogenicity scores (Fig 3).
3. Average database release cycle length for releases between August 2013 and July 2019. All values are mean ± SD. Total of 25 Ensembl, 13 GENCODE, six CCDS (homo sapien only), and five NCBI releases were counted. UniProtKB value was calculated by taking the average of release cycle lengths reported on the UniProt website.