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. 2021 Feb 11;8(1):ENEURO.0358-20.2020. doi: 10.1523/ENEURO.0358-20.2020

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Copyright © 2021 Chang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 5. — Gene regulation by Sox11 and Sox11^K91A in primary RGCs. A, Sox11 and Sox11^K91A upregulate several signaling pathways related to neuronal and axon growth. B, A volcano plot highlighting selected genes that are more downregulated by Sox11^K91A than by Sox11 (in blue, 173 genes) and selected genes that are more upregulated by Sox11^K91A than by Sox11 (in red, 181 genes). C, Spp1 and Opn4 were significantly downregulated in Sox11-treated and Sox11^K91A-treated groups, confirmed by qRT-PCR (N = 3, *p < 0.05, **p < 0.01; N.S., no significant difference, by one-way ANOVA with post hoc t test with Tukey correction; mean ± SEM shown).