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. 2020 Jan 29;124(3):251–260. doi: 10.1016/j.bja.2019.11.034

Table 4.

Preoperative assessment of patients on immune checkpoint inhibitors. 6MWT, 6 min walk test; ACTH, adrenocorticotropic hormone; HbA1c, haemoglobin A1C; ICI, immune checkpoint inhibitor; TSH, thyroid stimulating hormone.

Preoperative assessment
History
Assessment of cardiopulmonary function; detailed history of common treatment-related events (endocrine and organ-specific complications) after initiation of immune checkpoint inhibitors.
Laboratory tests
Basic: complete blood count, complete metabolic panel
Endocrine: TSH, free T4, HbA1c, ACTH, cortisol, cortisol stimulation test (may not be feasible in all patients on ICI)
Cardiac: baseline troponins at 6 weeks after treatment, B-natriuretic peptide
Studies

  • Cardiac:

  • -

    ECG

  • -

    Transthoracic echocardiogram if pre-existing cardiovascular disease merits

  • Pulmonary:

  • -

    Pulmonary function tests

  • -

    Chest radiograph, CT scan

  • -

    6 minute walk test

  • -

    Baseline oxygen saturation at rest and ambulation

  • -

    Referral to pulmonary medicine to evaluate pneumonitis if indicated by CT findings or symptoms