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. 2021 Feb 17;20:15. doi: 10.1186/s12944-021-01437-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Alterations of phospholipid and acyl glycerol classes were observed in non-cancerous prostate cells (blue), hormone-sensitive (dark red), castration-resistant (CR) (green), and Docetaxel resistant (DR) (red) prostate cancer cells. LC-ESI-MS/MS analysis of these classes in comparison to the Kennedy Pathway demonstrates alterations of the lipid abundance within progressing prostate cancer cells. The enzymes mediating the remodeling are shown in blue along the arrows. CHPT1 Cholinephosphotransferase 1, CEPT1 Choline/ethanolaminephosphotransferase 1, DAG diacylglycerol, DGAT diacylglycerol acyltransferase, PA phosphatidic acid, PAP phosphatidic acid phosphatase, PC phosphatidylcholine, PLD Phospholipase D, PE phosphatidylethanolamine, PEMT Phosphatidylethanolamine-N-methyltransferase, PG phosphatidylglycerol, PGP phosphatidylglycerol phosphatase, PS phosphatidylserine, PSS1/ PSS2 phosphatidylserine synthase, PISD Phosphatidylserine decarboxylases, TAG triacylglycerol