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. 2021 Feb 18;20:16. doi: 10.1186/s12944-021-01441-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Common and specific metabolites in psoriasis patients with or without coronary heart disease. a. sPLS-DA score plots of the CON, PSO, PC and CV groups in study cohort 2. The CON group is indicated with green circles, the PSO group with red circles, the PC group with blue circles, and the CV group with yellow circles. b. Venn diagram of the 25 overlapping metabolites in the PSO, CV and PC groups compared with the CON group in study cohort 2. c. Heatmap of the 25 overlapping metabolites in the PSO, PC and CV groups (all compared with the CON group). d. The bar plots represent, from left to right, the log (fold change value) and -log(P-value) from t-test analysis in the PC/PSO comparison in study cohort 2. CON: group of healthy controls; PSO: group of psoriasis patients; PC: group of psoriasis patients with coronary heart disease; CV: group of coronary heart disease patients without psoriasis