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. 2021 Feb 4;11:603979. doi: 10.3389/fphar.2020.603979

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Copyright © 2021 Alboni, Benatti, Colliva, Radighieri, Blom, Brunello and Tascedda.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental design: after habituation, animals were fed for 28 days with standard diet or vortioxetine-enriched diet (600 mg base per kg of food) and then intraperitoneally injected with lipopolysaccharide (LPS 830 μg/kg) or an equal volume of vehicle (pyrogen-free saline). (A) A group of animals (cohort 1; n = 48) was tested 6 and 24 h after the immune challenge for LPS-induced behaviors and depressive-like behavior, respectively. (B) An independent group of animals (cohort 2; n = 39) was sacrificed 6 h after LPS or saline injection for molecular analyses.