Table 1.
Demographics and Clinical Characteristics of Patients Who Required Thyroid Hormone Replacement Following Thyroid Lobectomy.
| Patients, No. (%)a | ||||
|---|---|---|---|---|
| Total (N = 369) | No hormone replacement (n = 258) | Hormone replacement (n = 111) | P value | |
| Age, y | ||||
| Mean ± SD | 43.8 ± 12.3 | 42.6 ± 12.3 | 46.6 ± 12.4 | .005 |
| 18-29 | 65 (17.6) | 50 (19) | 15 (14) | |
| 30-49 | 174 (47) | 130 (50) | 44 (40) | |
| ≥50 | 130 (35) | 78 (46) | 52 (47) | .002 |
| Sex: female | 278 (75) | 191 (74) | 87 (78.4) | .364 |
| Body mass index, mg/kg2, mean ± SD | 28.8 ± 6.3 | 28.6 ± 6.0 | 29.4 ± 7.0 | .288 |
| Family history of thyroid disease | 75 (24.5) | 45 (21.5) | 30 (30.9) | .087 |
| Preoperative TSH, mIU/L | ||||
| Mean ± SD | 1.34 ± 1.08 | 1.65 ± 1.13 | 1.21 ± 1.06 | <.001 |
| <0.4 | 36 (11) | |||
| 0.4 to <2.5 | 262 (79) | |||
| 2.5 to <4.0 | 27 (8) | |||
| ≥4.0 | 7 (2) | |||
| ≥2.5 | 34 (10) | 14 (6) | 20 (20) | <.001 |
| Postoperative (<3 mo) | ||||
| Symptoms | 50 (13.7) | 31 (12) | 19 (17) | .202 |
| Complications | 21 (4) | 22 (9) | 9 (8.1) | .886 |
| Temporary TVC weakness | 5 (1.4) | |||
| Permanent TVC weakness | 0 | |||
| Seroma | 3 (0.83) | |||
| Hematoma | 2 (0.55) | |||
| Hypocalcemia | 1 (0.28) | |||
| Lobe volume, cm3, mean ± SD | ||||
| Remaining | 6.5 ± 5.8 | 6.5 ± 5.3 | 6.4 ± 7.0 | .902 |
| Resected | 22.2 ± 22.3 | 22.7 ± 22.6 | 21.2 ± 21.8 | .563 |
| Resected lobe weight, g, mean ± SD | 20.7 ± 18.7 | 20.7 ± 18.6 | 20.6 ± 19.1 | .949 |
| Final pathology | ||||
| Benign | 329 (89) | 240 (92.9) | 89 (79.6) | <.001 |
| Follicular adenoma | 188 (57.1) | |||
| Multinodular goiter | 129 (39.2) | |||
| Otherb | 4 (1.2) | |||
| Malignant | 40 (11.0) | 18 (7.1) | 22 (20.4) | .0002 |
| Papillary thyroid carcinoma | 35 (87.5) | |||
| Follicular thyroid carcinoma | 4 (10) | |||
| Squamous cell carcinoma | 1 (2.5) | |||
| Thyroiditis on pathology report: positive | 68 (19.0) | 43 (17.1) | 25 (23.6) | .184 |
| Follow-up, mo, mean ± SD (range) | ||||
| In person | 2.17 ± 4.0 (0.03-31.2) | 1.69 ± 2.6 | 3.38 ± 6.2 | .01 |
| Electronic | 74.8 ± 41.7 (0.43-160) | 72.9 ± 42.7 | 79.7 ± 39.3 | .138 |
Abbreviations: THS, thyroid-stimulating hormone; TVC, true vocal cord.
a
Values are presented as No. (%) unless noted otherwise.
b
Two cases of colloid cysts and 2 cases of parathyroid cysts.