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. 2021 Feb 18;19:18. doi: 10.1186/s12969-021-00505-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — P. acnes detected by PAB antibody within the sarcoid granulomas of biopsied skin lesion. Hematoxylin and eosin stain and IHC with PAB antibody and LAM antibody as control are shown pairwise. a Noncaseating epithelioid cell granulomas in the dermis. b Higher magnification of the granuloma indicated by an arrow in (a). c No positive signal detected by LAM antibody in the identical granuloma. d Many round bodies detected by PAB antibody in the granuloma (arrows). Scale bar; 50 µm.

IHC, immunohistochemistry; PAB, Propionibacterium acnes-specific monoclonal; LAM, mycobacteria-specific monoclonal