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. 2021 Feb 17;21:116. doi: 10.1186/s12935-021-01822-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Various drug resistance mechanisms associated with Nrf2. SIRT5,CD99,ABCG2/HO-2,HER1,HER2/HER3,ABCF2,GPX4,AKR1C1 and CBS have a positive relationship with Nrf2 as molecules regulated by Nrf2 or regulating Nrf2;while ATF and SLC40A1 have a negative relationship with Nrf2; As the transcription target of Nrf2, p62/SQSTM1 competes with Nrf2 for binding with Keap1 and form a positive feedback loop between p62 and Nrf2.(“→” represents “activation” “— ” means “inhibition”.)