Table 6.

Serum RAAS levels in relation to different ACE2 SNPs among participants with or without T2D

ACE2 SNPs	ACE (U/L)			Renin (pg/mL)			Ang I (ng/L)
	Non-T2D	T2D	P value	Non-T2D	T2D	P value	Non-T2D	T2D	P value
rs2074192
CC	40.3 ± 13.3	40.1 ± 15.6	0.936	33.2 ± 24.6	44.1 ± 18.9	< 0.001	2.39 ± 0.84	2.68 ± 1.02	0.015
TT + CT	40.9 ± 8.1	43.0 ± 14.4	0.137	32.7 ± 24.1	47.4 ± 23.4	< 0.001	2.48 ± 0.85	2.68 ± 1.12	0.081
P value	0.656	0.118		0.868	0.189		0.389	0.995
rs4240157
CC + CT	38.9 ± 10.8	41.1 ± 15.4	0.243	34.5 ± 19.9	44.9 ± 21.4	0.001	2.37 ± 0.92	2.94 ± 0.97	< 0.001
TT	41.2 ± 10.2	41.9 ± 14.8	0.628	32.4 ± 25.5	46.5 ± 20.2	< 0.001	2.47 ± 0.82	2.47 ± 1.11	0.949
P value	0.117	0.682		0.501	0.539		0.449	< 0.001
rs4646188
CC + CT	41.5 ± 11.4	37.6 ± 17.0	0.113	33.7 ± 24.1	45.2 ± 20.7	0.002	2.43 ± 0.69	2.32 ± 1.00	0.450
TT	40.2 ± 9.7	42.7 ± 14.2	0.037	32.5 ± 24.4	45.9 ± 20.8	< 0.001	2.45 ± 0.93	2.79 ± 1.07	0.001
P value	0.306	0.017		0.704	0.814		0.788	0.002

ACE2 SNPs	Ang II (ng/L)			ALD (ng/L)
	Non-T2D	T2D	P value	Non-T2D	T2D	P value
rs2074192
CC	116.6 ± 62.1	162.9 ± 55.0	< 0.001	243.1 ± 73.8	224.7 ± 101.1	0.105
TT + CT	126.2 ± 81.3	135.1 ± 46.5	0.232	235.1 ± 82.5	276.9 ± 110.8	< 0.001
P value	0.305	< 0.001		0.419	< 0.001
rs4240157
CC + CT	118.9 ± 65.6	168.7 ± 46.8	< 0.001	233.2 ± 83.2	259.9 ± 107.5	0.085
TT	123.7 ± 77.2	132.6 ± 51.7	0.193	239.6 ± 78.1	243.8 ± 110.2	0.688
P value	0.655	< 0.001		0.574	0.225
rs4646188
CC + CT	127.4 ± 85.5	117.5 ± 48.5	0.345	244.5 ± 76.4	222.2 ± 85.6	0.082
TT	119.6 ± 67.2	158.3 ± 50.2	< 0.001	234.3 ± 80.9	259.9 ± 114.0	0.011
P value	0.406	< 0.001		0.306	0.005