Table 2.
Mutation spectra of the gpt gene in sperm of the AA-treated mice
| 28 + 3d | 28 + 49d | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 mg/kg/day | 30 mg/kg/day | 0 mg/kg/day | 30 mg/kg/day | |||||||||
| No. | % | MF (×10−6) | No. | % | MF (×10−6) | No. | % | MF (×10−6) | No. | % | MF (×10−6) | |
| Base substitution | ||||||||||||
| Transition | ||||||||||||
| G:C to A:T | 4 | 50.0 | 0.59 | 7 | 31.8 | 2.15 | 8 | 72.7 | 1.36 | 6 | 50.0 | 0.67 |
| at CpG site | (2) | (5) | (4) | (4) | ||||||||
| A:T to G:C | 0 | 0.0 | 0.00 | 1 | 4.5 | 0.31 | 1 | 9.1 | 0.17 | 1 | 8.3 | 0.11 |
| Transversion | ||||||||||||
| G:C to T:A | 1 | 12.5 | 0.15 | 6 | 27.3 | 1.85* | 0 | 0.0 | 0.00 | 2 | 16.7 | 0.22 |
| G:C to C:G | 0 | 0.0 | 0.00 | 1 | 4.5 | 0.31 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 |
| A:T to T:A | 1 | 12.5 | 0.15 | 1 | 4.5 | 0.31 | 0 | 0.0 | 0.00 | 1 | 8.3 | 0.11 |
| A:T to C:G | 0 | 0.0 | 0.00 | 1 | 4.5 | 0.31 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 |
| Deletion | 2 | 25.0 | 0.30 | 4 | 18.2 | 1.23 | 2 | 18.2 | 0.34 | 2 | 16.7 | 0.22 |
| 1 bp | 1 | 3 | 2 | 1 | ||||||||
| > 2 bps | 1 | 1 | 0 | 1 | ||||||||
| Insertion | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 |
| Other | 0 | 0.0 | 0.00 | 1 | 4.5 | 0.31 | 0 | 0.0 | 0.00 | 0 | 0.0 | 0.00 |
| Total | 8 | 100 | 1.18 | 22 | 100 | 6.77 | 11 | 100 | 1.87 | 12 | 100 | 1.34 |
*p < 0.05 vs control