Table 1.

Baseline characteristics of subjects

Age, years	71.8 ± 7.0
Gender, M/F	80/50
BMI, kg/m2	25.9 ± 4.3
Plasma glucose, mmol/L	4.9 ± 0.5
Plasma insulin, mIU/L	8.4 ± 7.3
HbA1c, mmol/mol	37.1 ± 6.6
HOMA2, mass units	1.1 ± 0.9
HOMA2%β	98.6 ± 63.5
HOMA2%S	147.6 ± 105.1
Total serum cholesterol, mmol/L	4.9 ± 1.3
LDL cholesterol, mmol/L	2.9 ± 1.0
HDL cholesterol, mmol/L	1.7 ± 0.6
Serum triglycerides, mmol/L	1.6 ± 0.8
On treatment with AchE-I (% of total)	82.9
On treatment with antidepressants (% of total)	25.5
MMSE	24.1 ± 3.1
CDR-SoB	3.6 ± 1.8
ADAS-Cog	31.9 ± 9.9
GDS	5.5 ± 4.7
ADCS—ADL	66.6 ± 9.1
COWAT average (total acceptable words)	10.2 ± 4.8 (30.1 ± 13.6)
Category fluency test (animals)	10.6 ± 5.1
NPI	9.6 ± 11.6
NPI—caregiver distress	5.0 ± 6.1
Anterior cingulate rCMRGlc, μmol/g/min	0.27 ± 0.05
Posterior cingulate rCMRGlc, μmol/g/min	0.30 ± 0.05
Frontal lobe rCMRGlc, μmol/g/min	0.31 ± 0.05
Temporal lobe rCMRGlc, μmol/g/min	0.23 ± 0.04
Parietal lobe rCMRGlc, μmol/g/min	0.26 ± 0.05
Occipital lobe rCMRGlc, μmol/g/min	0.28 ± 0.05
Medial Temporal lobe rCMRGlc, μmol/g/min	0.19 ± 0.03
Hippocampal rCMRGlc, μmol/g/min	0.19 ± 0.03
Thalamus rCMRGlc, μmol/g/min	0.25 ± 0.05
Striatum rCMRGlc, μmol/g/min	0.30 ± 0.05
Hippocampal volume, mm3	3062.2 ± 458.6
White matter lesions volume, ml	6.79 ± 7.7
Total grey matter volume, mm3	556,401.9 ± 52,622.8

Continuous data are shown as mean ± standard deviation