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. 2021 Feb 4;9:628649. doi: 10.3389/fcell.2021.628649

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Copyright © 2021 Cao, Zhao, Wang, Cai, Xia, Zhang, Han, Xu, Zhang, Ling, Ma and Huo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Y217N variants on PATL2 degradation. (A,B) The Patl2 levels in oocytes at germinal vesicle (GV), meiosis metaphase I (MI), and meiosis metaphase II (MII) stages were determined by western blot. (C) Immunostaining of Patl2 in oocytes at GV, MI, and MII stages. Scale bar, 20 μm. (D) Ubiquitination was evaluated by co-IP with an anti-FLAG antibody. (E,F) The PATL2 stability comparison between group of PATL2^WT or PATL2^Y217N transfected cells is followed by CHX treatment. ***p < 0.001.