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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Exp Clin Psychopharmacol. 2020 Jul 13;29(4):319–333. doi: 10.1037/pha0000399

Figure 5.

Figure 5.

No sex differences in variable-ratio (VR)-based self-administration in mice. Panel A: Active and inactive responses for female and male mice during cocaine self-administration. Male and female mice showed similar preference for active nose poke compared to inactive. Panel B: Cocaine infusions for female and male mice during cocaine self-administration. Female and male mice self-administered similar levels of cocaine. Panel C: Total cocaine consumption in self-administration (VR3 and VR5). Female and male mice consumed similar levels of cocaine. Panel D: Female and male mice acquired bias for active nose poke at similar rates during cocaine self-administration. Panel E: Female and male animals excluded based on VR criteria. Data reported as mean ± standard error of the mean. FR = fixed ratio.