Extended Data Fig. 1. Longitudinal viral RNA determination following SARS-CoV-2 infection in rhesus macaques.

Viral RNA (log₁₀ copies/mL measured by RT-PCR in buccopharyngeal (a) swab, plasma (b) and urine (c) of rhesus macaques longitudinally ³⁹. Subgenomic viral RNA (log₁₀ copies/gram of lung tissue was measured at endpoint in rhesus macaques and (d) and Baboons (e). (Rhesus: Old-Triangle, Young-Diamonds; Baboon: Old-Inverted triangle, Young-Square, Colors represent individual animals, Supplementary Table 1). (n=12). Data are represented as mean± SEM. Two way Repeated-measures ANOVA with Geisser-Greenhouse correction for sphericity and Tukey’s post hoc correction for multiple-testing (GraphPad Prism 8) was applied. Correlations with Spearman’s rank test between Log10 viral RNA copy number in Lung with BAL and NS (f) and corresponding values for Spearman’s rank correlation coefficient (g) and P values (h). Coloring scheme for f – BAL (magenta circle), NS (teal square).