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. 2021 Feb 17;40:72. doi: 10.1186/s13046-021-01868-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — MAPKAPK5-AS1 upregulation is associated with poor clinical features and prognosis in HCC. a TCGA dataset showed the high expression level of MAPKAPK5-AS1 in HCC tissues compared to normal tissues. b GSE45436 dataset further exhibited high expression level of MAPKAPK5-AS1 in HCC tissues. c The level of MAPKAPK5-AS1 in 97 pairs HCC tissues and adjacent non-tumor tissues. d Kaplan-Meier survival analysis showed that HCC patients with high MAPKAPK5-AS1 expression exhibited a worse overall survival. e-f TCGA data showed that high MAPKAPK5-AS1 expression indicated poor overall survival (OS) and disease-free survival (DFS)