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. 2021 Feb 17;40:72. doi: 10.1186/s13046-021-01868-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — Hypoxia triggers a MAPKAPK5-AS1/PLAGL2/HIF-1α signaling loop. a Heat map of RNA-seq data exhibited the upregulation of MAPKAPK5-AS1 under hypoxia. b The upregulation of MAPKAPK5-AS1 and PLAGL2 induced by hypoxia was suppressed by HIF-1α knockdown. c The recognition motif of HIF-1α from JSAPAR database. d The hypoxia responsive element (HRE) in MAPKAPK5-AS1 promoter. In addition, the result of luciferase reporter assay is exhibited. e ChIP assay was conducted to validate the binding between HIF-1α and the HRE of the lncRNA MAPKAPK5-AS1 promoter under normoxia and hypoxia. f The regulatory effect of MAPKAPK5-AS1 on HIF-1α and PLAGL2 level. d The effect of PLAGL2 on HIF-1α and MAPKAPK5-AS1 expression under hypoxia. *p < 0.05