Table 2.
Observed rate of FEV1 decline according to GOLD subgroups, gender, smoking status and BMI category
| GOLD Grades 1 and 2 | |||
|---|---|---|---|
| Male (N = 5457) |
Female (N = 3229) |
p-value* | |
| Rate of FEV1 decline, mean (95% CI), mL/year |
− 36.6 (− 37.6, − 35.6) |
− 29.2 (− 30.2, − 28.1) |
p < 0.001 |
| Age, y, mean (SD) | 51.8 (8.8) | 51.9 (9.3) | p = 0.40 |
| BMI, kg/m2, mean(SD) | 26.3 (3.9) | 24.8 (4.7) | p < 0.001 |
| BMI category, n (%) | p < 0.001 | ||
| Underweight (BMI < 18.5) | 54 (1.0) | 109 (3.4) | |
| Normal (BMI 18.5–25.0) | 2082 (38.2) | 1,863 (57.7) | |
| Overweight (BMI 25.1–30.0) | 2477 (45.4) | 863 (26.7) | |
| Obese (BMI > 30.1) | 844 (15.5) | 394 (12.2) | |
| Smoking status, n (%) | p = 0.02 | ||
| Ex-smoker | 1472 (45.7) | 2350 (43.1) | |
| Current smoker | 1750 (54.3) | 3099 (56.9) | |
BMI body mass index, GOLD Global Initiative for Chronic Obstructive Lung Disease (GOLD) spirometric grades, N number, SD standard deviation
*p-values were obtained from Kruskal–Wallis test for continuous variables and Pearson chi-square test for categorical variables