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. 2021 Feb 18;16:9. doi: 10.1186/s13024-021-00432-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Fundus images and green fluorescence images of different mice. a Fundus images were taken using the topic endoscopic fundus imaging (TEFI) system from young (3-month) and aged (12-month old) Socs3^fl/fl mice, LysMCre-Socs3^fl/fl mice, Cx3cr1^gfp/gfp (CX3CR1 KO) mice, and DKO mice. Arrow – a patch of whitish lesion; arrowheads – multiple whitish dots. b Fundus green fluorescence images were taken from 3-month or 12-month old Cx3cr1^gfp/gfp and DKO mice using Micron IV. Arrows – patches of GFP aggregations; arrowheads – perivascular macrophages. OD – optic disc