Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 3;11:603059. doi: 10.3389/fimmu.2020.603059

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Knoop, McDonald, Hsieh, Tarr and Newberry

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Deletion of Tregs on DOL24, but not DOL14, abrogates oral tolerance later in life. (A) Schematic, FoxP3-DTR mice were injected with diphtheria toxin on DOL14 (green) or DOL24 (orange), control mice were injected with diphtheria toxin on DOL24 (gray). (B) Absolute number of Foxp3+ or RORγt+FoxP3+ colon LP cells analyzed on DOL 28 or DOL120. (C) Increase in footpad thickness following 7 days of Ova in drinking water, immunization, and footpad challenge with Ova, analyzed by one-way ANOVA with Dunnett’s test for multiple comparison. n = 4 mice per group in panels b and c, *denotes statistical significance < 0.05, ns, not significant.