Extended Data Table 2. Association between variant allele fraction (VAF) of CH mutations and clinical characteristics.

Generalized estimating equations were used to test for association between VAF of CH mutations (among those with a mutation) and selected clinical and mutational features, accounting for correlation between the VAF of mutations in the same person. Age expressed in decile.

Variable (ref)		OR	95% CI	p
Age	-	1	1–1.1	0.0011
Ethnicity (white)	Asian	1	0.94–1.2	0.42
	Black	0.9	0.82–1	0.053
	Other	0.93	0.83–1	0.24
	Unknown	0.92	0.8–1.1	0.22
Smoking status (non-smoker)	Smoker	1.1	1.1–1.2	0.000023
Therapy (untreated)	Treated	1	0.96–1.1	0.8
PD status (Non-PD non-myeloid)	Myeloid PD	1.3	1.3–1.4	< 1 × 10−6
	Non-myeloid PD	1.3	1.2–1.5	0.000052
	Non-PD myeloid	0.99	0.92–1.1	0.8
Number of mutations (1)	≥ 2	1.1	1.1–1.2	0.0000038